@article{JBUON2018;23(6):1911,
title = {Drug repurposing: mebendazole as effective antitumor agent. Are we seeing the whole story?},
author = {Pavle Banović and Srđan Stankov and Nenad Vranješ and Ognjen Zurković and Ivan Čapo and Dušan Lalošević},
url = {https://www.pasterovzavod.rs/wp-content/uploads/2019/02/23-6-1904-1911-2.pdf},
issn = {1107-0625, online ISSN: 2241-6293},
year = {2018},
date = {2018-06-09},
journal = {JBUON},
volume = {23},
number = {6},
pages = {1904-1911},
institution = {Medical Faculty Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia; Medical Faculty Novi Sad, University of Novi Sad, Department of Histology and Embryology, 21000 Novi Sad, Serbia; Pasteur Institute Novi Sad, 21000 Novi Sad, Serbia},
abstract = {Purpose: To examine the antitumor effects of Mebendazole (MZ) in a model of experimental fibrosarcoma induced by inoculation of BHK-21/C13 cells in Syrian golden hamster.

Methods: Hamsters were inoculated with a suspension of BHK cells by subcutaneous injection and randomly divided into 5 experimental and 2 control groups. Treatment started on the 10th day after inoculation, when the tumor grew to a diameter of 5mm. The experimental design was based on distributing the total amount of drug MZ(z) in different protocols and approaches (oral/intraperitoneal) to the 5 experimental groups. The positive control group received doxorubicin intraperitoneally. Negative control group received olive oil orally. The total amount of MZ(z) was chosen to be the highest for the animal to survive during the experiment. For antitumor effect evaluation, the main parameters were tu mor size, number of mitoses, cytochrome-C immunopositivity and tumor tissue morphology incuding cytoarchitecture and percentage of preserved tumor tissue in stereologically reconstructed tumor mass.

Results: The results of this study showed absence of objective MZ antitumor effect on experimental fibrosarcoma. MZ does not exhibit activity similar to DNA-damaging agents on the fibrosarcoma model.

Conclusions: It might be postulated that soft tissue tumors on animal models could show high level of resistance to MZ effect.
},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

@article{Helminthologia,
title = {Respiratory and cardiopulmonary nematode species of foxes and jackals in Serbia},
author = {Olivera Bjelić Čabrilo and Verica Simin and Vilan Miljević and Borislav Čabrilo and Dragana Mijatović and Dušan Lalošević},
url = {https://www.pasterovzavod.rs/wp-content/uploads/2019/02/13369083-Helminthologia-Respiratory-and-cardiopulmonary-nematode-species-of-foxes-and-jackals-in-Serbia.pdf},
doi = {10.2478/helm-2018-0019},
issn = {3},
year = {2018},
date = {2018-05-07},
journal = {SCIENDO / Helminthologia},
volume = {5},
pages = {213–221},
abstract = {As part of routine monitoring of foxes (Vulpes vulpes) and jackals (Canis aureus) on the territory of Vojvodina province (northern Serbia), an analysis of respiratory and cardiopulmonary parasitic nematodes was conducted. Both host species harbored Eucoleus aerophilus, E. boehmi and Crenosoma vulpis, whereas Angiostrongylus vasorum was found only in foxes. A high prevalence of infection (72.6 %) was noted for E. aerophilus in foxes. The remaining parasite species occurred less frequently in both host species. In all species where it could be quantifi ed, a high degree of parasite aggregation within host individuals was noted. Single species infections were most common, whereas two and three species infections occurred less frequently in both host species. The distribution of abundance of E. aerophilus was affected by host sex, with abundances higher in male foxes. Sampling site and year infl uenced abundance variation in E. boehmi. },
keywords = {},
pubstate = {published},
tppubtype = {article}
}