Publications and scientific papers of Pasteur Institute…
PUBLICATIONS
2024 |
|
Banović, Pavle; Mijatović, Dragana; Simin, Verica; Vranješ, Nenad; Meletis, Eleftherios; Kostoulas, Polychronis; Obregon, Dasiel; Cabezas-Cruz, Alejandro Real-world evidence of rabies post-exposure prophylaxis in Serbia: Nation-wide observational study (2017–2019) Journal Article In: Travel Medicine and Infectious Disease, 2024. Abstract | Links | BibTeX | Tags: immunization, Rabies, seroconversion, vaccine @article{nokey, Background Rabies remains a deadly zoonotic disease, primarily prevalent in Eastern European countries, with a significant global burden in Asia and Africa. Post-exposure prophylaxis (PEP) is critical to prevent clinical rabies. Serbia, a country with a relatively low animal rabies incidence, has been implementing a 4-dose Essen PEP regimen for 13 years. This real-world study aimed to assess the effectiveness of the 4-dose Essen regimen, considering demographic and clinical factors, after WHO Category III exposure. Method The study included 601 patients who received the 4-dose Essen PEP and 79 who received an additional 5th dose. Results Age emerged as a critical factor influencing seroconversion rates after the 4-dose regimen, with older individuals exhibiting lower RVNA titers. Logistic regression indicated a 3.18% decrease in seroconversion odds for each added year of age. The Cox proportional hazards mixed model highlighted age-related risks, with age groups 45–60 and 75–92 at the highest risk of non-seroconversion. Human Rabies Immune Globulin (HRIG) administration was associated with lower RVNA values after the 4-dose regimen, suggesting interference with vaccine immunogenicity among people who received larger doses of HRIG. Conclusions This study provides valuable real-world evidence for rabies PEP in a non-homogeneous population with potential comorbidities. The results underscore the importance of optimizing PEP strategies, particularly in older individuals, and reconsidering HRIG dosing to improve seroconversion rates. | |
2022 |
|
M, Kunze; P, Banović; P, Bogovič; V, Briciu; R, Čivljak; G, Dobler; A, Hristea; J, Kerlik; S, Kuivanen; Kynčl, J; A-M, Lebech; L, Lindquist; I, Paradowska-Stankiewicz; S, Roglić; D, Smíšková; F, Strle; O, Vapalahti; N, Vranješ; N, Vynograd; JM, Zajkowska; A, Pilz; A, Palmborg; Erber, W Recommendations to Improve Tick-Borne Encephalitis Surveillance and Vaccine Uptake in Europe Journal Article In: Microorganisms, vol. 10, no. 7, 2022. Abstract | Links | BibTeX | Tags: Incidence, recommendations, tick-borne encephalitis (TBEV), vaccine, Western Europe @article{M2022, There has been an increase in reported TBE cases in Europe since 2015, reaching a peak in some countries in 2020, highlighting the need for better management of TBE risk in Europe. TBE surveillance is currently limited, in part, due to varying diagnostic guidelines, access to testing, and awareness of TBE. Consequently, TBE prevalence is underestimated and vaccination recommendations inadequate. TBE vaccine uptake is unsatisfactory in many TBE-endemic European countries. This review summarizes the findings of a scientific workshop of experts to improve TBE surveillance and vaccine uptake in Europe. Strategies to improve TBE surveillance and vaccine uptake should focus on: aligning diagnostic criteria and testing across Europe; expanding current vaccine recommendations and reducing their complexity; and increasing public education of the potential risks posed by TBEV infection. |