@article{Grujic2022,

title = {Personal Freedom and Public Responsibility: Remaining Questions after First Case of HIV Transmission via Blood Transfusion in North Serbia},

author = {Jasmina Grujic and Nevenka Bujandric and Pavle Banović},

editor = {Vito Fiore},

doi = {https://doi.org/10.3390/healthcare10081397},

year  = {2022},

date = {2022-07-27},

urldate = {2022-07-27},

journal = {Healthcare},

volume = {10},

number = {8},

abstract = {The reduction in the risk of transfusion-transmissible infections (including HIV infection) is an essential part of transfusion patient care. Here, we report the first incident of HIV transmission via transfusion in north Serbia due to blood donor dishonesty, and the failure of the laboratory screen tests to detect the presence of HIV particles in his blood. Infected blood products were distributed to two recipients, and HIV infection was confirmed in one. This incident finally led to the implementation of Nucleic Acid Amplification Technology as mandatory testing of blood donors for HIV infection in Serbia and raised many questions related to the responsibility and ethics of all the participants in the blood transfusion supply chain. There is a need for the implementation of modern and non-discriminative laws in Serbia in order to reduce transfusion-transmissible infections. In addition, transfusion institutes in Serbia need to be obliged to pursue the constant upgrade of their diagnostic capacities in order to prevent similar incidents and to provide the best possible care for blood donation recipients.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{M2022,

title = {Recommendations to Improve Tick-Borne Encephalitis Surveillance and Vaccine Uptake in Europe},

author = {Kunze M and Banović P and Bogovič P and Briciu V and Čivljak R and Dobler G and Hristea A and Kerlik J and Kuivanen S and Kynčl, J and Lebech A-M and Lindquist L and Paradowska-Stankiewicz I and Roglić S and Smíšková D and Strle F and Vapalahti O and Vranješ N and Vynograd N and Zajkowska JM and Pilz A and Palmborg A and Erber, W},

editor = {Pat Nuttall},

doi = {https://doi.org/10.3390/microorganisms10071283},

year  = {2022},

date = {2022-06-27},

journal = {Microorganisms},

volume = {10},

number = {7},

abstract = {There has been an increase in reported TBE cases in Europe since 2015, reaching a peak in some countries in 2020, highlighting the need for better management of TBE risk in Europe. TBE surveillance is currently limited, in part, due to varying diagnostic guidelines, access to testing, and awareness of TBE. Consequently, TBE prevalence is underestimated and vaccination recommendations inadequate. TBE vaccine uptake is unsatisfactory in many TBE-endemic European countries. This review summarizes the findings of a scientific workshop of experts to improve TBE surveillance and vaccine uptake in Europe. Strategies to improve TBE surveillance and vaccine uptake should focus on: aligning diagnostic criteria and testing across Europe; expanding current vaccine recommendations and reducing their complexity; and increasing public education of the potential risks posed by TBEV infection.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Banović2022b,

title = {Unexpected TBEV Seropositivity in Serbian Patients Who Recovered from Viral Meningitis and Encephalitis},

author = {Pavle Banović and Adrian Alberto Díaz-Sánchez and Selena Đurić and Siniša Sević and Vesna Turkulov and Dajana Lendak and Sandra Stefan Mikić and Verica Simin and Dragana Mijatović and Ivana Bogdan and Aleksandar Potkonjak and Sara Savić and Dasiel Obregón and Alejandro Cabezas-Cruz},

editor = {Libor Grubhoffer},

doi = {10.3390/pathogens11030371},

year  = {2022},

date = {2022-03-17},

journal = {Pathogens},

abstract = {The tick-borne encephalitis virus (TBEV) causes a life-threatening disease named Tick-borne encephalitis (TBE). The clinical symptoms associated with TBE range from non-specific to severe inflammation of the central nervous system and are very similar to the clinical presentation of other viral meningitis/encephalitis. In consequence, TBE is often misclassified by clinical physicians , mainly in the non-identified high-risk areas where none or only a few TBE cases have been reported. Considering this situation, we hypothesized that among persons from northern Serbia who recovered from viral meningitis or encephalitis, there would be evidence of TBEV infection. To test this hypothesis, in this observational study, we evaluated the seroreactivity against TBEV anti-gens in patients from northern Serbia who were hospitalized due to viral meningitis and/or viral encephalitis of unknown etiology. Three cases of seroreactivity to TBEV antigens were discovered among convalescent patients who recovered from viral meningitis and/or encephalitis and accepted to participate in the study (n = 15). The clinical and laboratory findings of these patients overlap with that of seronegative convalescent patients. Although TBE has been a notifiable disease in Serbia since 2004, there is no active TBE surveillance program for the serologic or molecular screening of TBEV infection in humans in the country. This study highlights the necessity to increase the awareness of TBE among physicians and perform active and systematic screening of TBEV antibodies among patients with viral meningitis and/or encephalitis.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Stankov2021,

title = {O značaju higijenskih mera u suzbijanju infektivnih bolesti koje se prenose respiratornim putem},

author = {Srđan Stankov},

doi = {https://doi.org/10.5937/smclk2-32327},

year  = {2021},

date = {2021-06-23},

journal = {Srpski medicinski časopis Lekarske komore},

volume = {2},

number = {1},

pages = {11-15},

publisher = {Lekarska komora},

abstract = {Zarazne bolesti su postojale u obliku epidemija tokom istorije čovečanstva, a patogeni mikroorganizmi su dugo bili smatrani odgovornim za njihovo pojavljivanje. Međutim, takozvani biološki agensi akutnih zaraznih bolesti nisu njihovi stvarni uzroci, već samo katalizatori već postojećih patoloških procesa. Otuda ekstremna varijabilnost lokacije i intenziteta patoloških procesa sa istim biološkim uzročnikom kod različitih jedinki vrste domaćina. Patogenost i virulencija mikroorganizama nisu njihova vlastita i nepromenljiva svojstva, već su samo rezultat patogenosti neživih faktora životne sredine koji deluju na domaćina i koji obično ostaju van fokusa medicinskih istraživanja. Pitanje od glavne praktične važnosti, kako da sprečimo pojavu zaraznih bolesti, daje nam istorija. U prošlosti su mnoge higijenske mere bile dovoljne da se većina zaraznih bolesti svede na neznatnu pojavu. Do sada je društvo puno uradilo na higijenskim standardima čvrstih i tečnih materija u našem okruženju. Međutim, briga o higijeni atmosfere i dalje je prilično nerazvijena i zanemarena. Danas se atmosfera neprekidno i sistematski zagađuje određenim gasovima, parama kao i česticama. Direktni rezultat ovakog stanja razvoja higijenske prakse je da su danas jedina vrsta epidemija koje pogađaju opštu populaciju epidemije koje se šire atmosferom, tj. respiratorne epidemije. Da bi se trajno eliminisala dalja mogućnost respiratornih epidemija, neophodno je uvesti trajne i sistematske mere za održavanje higijene atmosfere ljudskih naselja.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Banović2021c,

title = {A One Health approach to study the circulation of tick-borne pathogens: A preliminary study},

author = {Pavle Banović and Adrian Alberto Díaz-Sánchez and Clemence Galon and Angélique Foucault-Simonin and Verica Simin and Dragana Mijatović and Luka Papić and Alejandra Wu-Chuang and Dasiel Obregon and Sara Moutailler and Alejandro Cabezas-Cruz },

doi = {https://doi.org/10.1016/j.onehlt.2021.100270},

year  = {2021},

date = {2021-06-01},

journal = {One Health},

abstract = {Tick-borne pathogens (TBPs) have complex life cycles involving tick vectors and vertebrate hosts. However, there is limited empirical evidence on the zoonotic circulation of TBPs. In this study, we used a One Health approach to study the possible circulation of TBPs in ticks, animals and humans within a rural household in the foothills of the Fruška Gora mountain, northern Serbia. The presence of TBP DNA was assessed using microfluidic PCR (25 bacterial species, 7 parasite species, 5 bacterial genera, 3 parasite genera) in animal, human and tick samples and the presence of tick-borne encephalitis virus (TBEV) RNA was screened for using RT-qPCR on tick samples. In addition, Lyme borreliosis serology was assessed in patient sera. Rhipicephalus sanguineus and Ixodes ricinus ticks were identified on dogs and Haemaphysalis punctata was identified on house walls. Rickettsia helvetica was the most common pathogen detected in pooled R. sanguineus and I. ricinus tick samples, followed by Hepatozoon canis. None of the H. punctata tick samples tested positive for the presence of TBPs. Anaplasma phagocytophilum and Rickettsia monacensis were the most frequent pathogens detected in dogs, followed by Rickettsia felis, whereas Anaplasma bovis was the only pathogen found in one of the goats tested. None of the human blood samples collected from family members tested positive for the presence of TBPs. Although microfluidic PCR did not detect Borrelia sp. in any of the tested tick or blood samples, a family member with a history of Lyme disease was seropositive for Borrelia burgdorferi sensu lato (s.l.). We conclude that, despite the presence of TBPs in tick and vertebrate reservoirs, there is no evidence of infection with TBPs across various components of the epidemiological chain in a rural Fruška Gora household.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ristić2021,

title = {Uticaj hroničnog imobilizacionog stresa na estrusni ciklus kod ženki miševa soja NMRI},

author = {Jelena Ristić and Damir Bogdan and Pavle Banović},

doi = {10.5937/mp72-28778},

year  = {2021},

date = {2021-05-20},

journal = {Medicinski podmladak},

volume = {72},

number = {1},

pages = {6-11},

abstract = {Uvod: Stres je skup reakcija organizma koje nastaju usled dejstva faktora spoljašnje sredine. Da bi se održala homeostaza i zaštitio organizam, uključuju se brojni adaptacioni mehanizmi. Stresori koji deluju trenutno ili kratkoročno izazivaju akutni stres koji ima protektivni efekat. Kada stresor deluje duže, a organizam ne uspeva da odgovori na izazov, javlja se hronični stres koji vodi u patološko stanje. Hronični stres je, kao etiološki faktor, doveden u vezu sa poremećajima menstrualnog ciklusa žena. Cilj: Cilj je ispitati dejstvo hroničnog imobilizacionog stresa na estrusni ciklus kod ženki miševa NMRI soja. Materijal i metode: Dvanaest polno zrelih ženki miševa NMRI soja nasumično je podeljeno u kontrolnu (n = 6) i eksperimentalnu grupu (n = 6). Eksperimentalnoj grupi je indukovan hronični stres ubacivanjem u imobilizacione komore 2 sata dnevno u periodu od 14 dana. Svakodnevno je svim životinjama uziman vaginalni ispirak od koga je pravljen razmaz radi ispitivanja pod svetlosnim mikroskopom. Analiza preparata je obuhvatala određivanje faza estrusnog ciklusa. Za analizu efekta stresa statistički je ispitana učestalost smenjivanja estrusnih faza u eksperimentalnoj grupi naspram kontrolne. Rezultati: Kod ženki miševa je uočen estrusni ciklus koji se sastoji iz četiri faze: proestrusa, estrusa, metestrusa i diestrusa. U adaptacionom periodu je zapažen prolongirani diestrus, dominantno prisutan u obe grupe. Kod stresiranih jedinki je uočen izlazak iz diestrusa i pojava drugih estrusnih faza, za razliku od kontrolnih kod kojih je diesterus bio znatno učestaliji. Zapažene su neregularnosti u trajanju i smenjivanju faza kod jedinki eksperimentalne grupe, gde se učestalost odstupanja od diestrusa pokazala kao statistički značajna (p < 0,01). Zaključak: Indukovanje imobilizacionog stresa dovodi do izlaska životinja iz diestrusa i velikih varijacija u trajanju i smenjivanju faza estrusnog ciklusa ženki miševa soja NMRI. S obzirom na to da je hormonski mehanizam regulacije estrusnog ciklusa kod ženki miševa soja NMRI sličan mehanizmu regulacije menstrualnog ciklusa kod žena, mogu poslužiti kao dobar model za proučavanje reproduktivnih poremećaja kod žena.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}