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National Reference Laboratory for Rabies Pasteur Institute Novi Sad

NOTIFICATION FOR VETERINARS THAT ARE SENDING ANIMAL SERA FOR FAVN TEST:

The FAVN form and payment slip from now on can be filled online, i.e. directly from Pasteur Institute website. After completing the form, on your e-mail will be sent a copy of the completed form as a PDF file. Print, sign, and authenticate the form, then send it with the sample marked with the number of microchip. In the future, it will still be possible to send manually filled requests, however, we encourage you to accept a new way to fill in the form. For all information, you can call 021 420-528

NOTICE FROM THE AMBULANCE FOR LYME BORRELIOSIS AND OTHER TICK-BORNE DISEASES:

If the tick is removed in another institution, for further analysis it is recommended to deliver ticks packed with damp wool or gauze in the reception of the ambulance for the Lyme borreliosis and other Tick-borne diseases of Pasteur Institute Novi Sad, or report personally if the tick has not been removed. In order to do the analysis of the ticks, it is NOT NECESSARY for tick be alive. For all information, you can call 021 420-528

Ambulance for Rabies Prevention

Patient reception is from 7:30 to 14:30 (Monday – Friday). In case of injures that are consequence of contact with animals, patients should report to their General Practitioner or to Emergency medical service.

For information regarding possible vaccination against Rabies please call:

064/ 39 33 821

Find nearestanti-rabies stationFind nearestanti-rabies station

Vivarium

Vivarium represents the organizational unit of the Pasteur Institute Novi Sad, within the Department of Microbiology.

Pasteur Institute as Museum of medicine

Due to its importance for the history of the health culture, and because of the architectural values of the building, Pasteur Institute in Novi Sad was established as a cultural monument According to Official Gazette of R. Serbia from 2001.

More informationsMore informations

FAVN test

Within the Serology Laboratory of Department of Microbiology, the determination of the titre of neutralizing specific anti-rabies virus by the FAVN method is performed.

Request FAVN formRequest FAVN form

FAVN result checkFAVN result check

NEWS

Continuous medical education held for first time at the Memorial House of the founder of the Pasteur Institute Dr. Adolf Hempt

Pasterov zavod08/03/2018

In the goal of educational activities which serve to maintain, develop, or increase the knowledge, skills, and professional performance of medical doctors, medical technicians, nurses ...

Delegation of Pasteur Institute on 10th Balkans congress of microbiology MICROBILOGIA BALKANICA 2017

Pasterov zavod20/11/2017

Microbiologia Balkanica represents traditional scientific and educational manifestation where microbiology experts from the countries of Balkan meet to exchange the ...

Previous newsPrevious news

Publikacije i naučni radovi Pasterovog zavoda…

PUBLICATIONS

2020
	Fedrigolli, Elsa; Bogdan, Damir; Lalošević, Dušan; Banović, Pavle Proposition Of A Simplified Protocol and New Parameter Introduction In NMRI Mice Anhedonia Induction Journal Article Forthcoming Serbian Journal of Experimental and Clinical Research, In press , Forthcoming. BibTeX @article{Fedrigolli2020, title = {Proposition Of A Simplified Protocol and New Parameter Introduction In NMRI Mice Anhedonia Induction}, author = {Elsa Fedrigolli and Damir Bogdan and Dušan Lalošević and Pavle Banović}, year = {2020}, date = {2020-04-30}, journal = {Serbian Journal of Experimental and Clinical Research}, volume = {In press}, keywords = {}, pubstate = {forthcoming}, tppubtype = {article} } Close
	Stankov, Srđan; Obradović, Nemanja; Vujin, Dragana; Vranješ, Nenad Possibility of Immediate Introduction of a Single-Dose Antibody Induction Test as a Refinement of the NIH Test for Inactivated Rabies Vaccine Potency Determination Journal Article Forthcoming Viral Immunology, pp. 1-11, Forthcoming. Abstract \| Links \| BibTeX @article{Stankov2020, title = {Possibility of Immediate Introduction of a Single-Dose Antibody Induction Test as a Refinement of the NIH Test for Inactivated Rabies Vaccine Potency Determination}, author = {Srđan Stankov and Nemanja Obradović and Dragana Vujin and Nenad Vranješ}, url = {https://www.liebertpub.com/doi/10.1089/vim.2019.0131}, doi = {10.1089/vim.2019.0131}, year = {2020}, date = {2020-03-10}, journal = {Viral Immunology}, pages = {1-11}, abstract = {Antibody induction test (AIT) is a promising candidate as a refinement of the troublesome National institutes of Health (NIH) test in the sense of animal welfare 3R approach for determination of potency of inactivated rabies vaccines for veterinary and human use. In this study, we initially try to develop AIT as a suitable alternative to NIH test, to achieve a reduction of test duration and diminish animal suffering by omitting intracerebral CVS infection and measuring humoral immunity upon vaccination. Designs of both multi-dose and single-dose AIT were examined. Biological reference preparation, batch 5 with assigned titer of 10 IU/vial, was taken as both standard and test vaccine. Six consecutive AITs were performed and eight pools of sera in each AIT were tested in triplicate by rapid fluorescent focus inhibition test. We estimated the upper detection limit and calculated test variability for individual dilutions. For multi-dose AIT, we estimated the dose–response function and performed calculations of final test results and statistical validity parameters for both linear and sigmoidal model using CombiStats program. Sigmoidal 4-parameter dose–response model was found optimal. Presented design of multi-dose AIT showed a satisfactory detection limit for testing of inactivated rabies vaccines for both veterinary and human use. However, due to nonconformity of obtained results with statistical validity criteria, we concluded that the presented model of multi-dose AIT was unsuitable for introduction in routine practice. However, we concluded that there was a realistic option for introduction of two versions of single-dose AIT. The first version would be with two standard vaccine controls and could be introduced immediately, while the second version would include testing of the sample only and rely on comparison of the induced rabies antibody level with absolute cut-off limits set in advance.}, keywords = {}, pubstate = {forthcoming}, tppubtype = {article} } Close Antibody induction test (AIT) is a promising candidate as a refinement of the troublesome National institutes of Health (NIH) test in the sense of animal welfare 3R approach for determination of potency of inactivated rabies vaccines for veterinary and human use. In this study, we initially try to develop AIT as a suitable alternative to NIH test, to achieve a reduction of test duration and diminish animal suffering by omitting intracerebral CVS infection and measuring humoral immunity upon vaccination. Designs of both multi-dose and single-dose AIT were examined. Biological reference preparation, batch 5 with assigned titer of 10 IU/vial, was taken as both standard and test vaccine. Six consecutive AITs were performed and eight pools of sera in each AIT were tested in triplicate by rapid fluorescent focus inhibition test. We estimated the upper detection limit and calculated test variability for individual dilutions. For multi-dose AIT, we estimated the dose–response function and performed calculations of final test results and statistical validity parameters for both linear and sigmoidal model using CombiStats program. Sigmoidal 4-parameter dose–response model was found optimal. Presented design of multi-dose AIT showed a satisfactory detection limit for testing of inactivated rabies vaccines for both veterinary and human use. However, due to nonconformity of obtained results with statistical validity criteria, we concluded that the presented model of multi-dose AIT was unsuitable for introduction in routine practice. However, we concluded that there was a realistic option for introduction of two versions of single-dose AIT. The first version would be with two standard vaccine controls and could be introduced immediately, while the second version would include testing of the sample only and rely on comparison of the induced rabies antibody level with absolute cut-off limits set in advance. Close https://www.liebertpub.com/doi/10.1089/vim.2019.0131 doi:10.1089/vim.2019.0131 Close
	Pavle, Banović; Čapo, Ivan; Ogorelica, Dejan; Vranješ, Nenad; Verica, Simin; Lalošević, Dušan Mysterious path of Borrelia spielmanii: spreading without morphological alteration of collagen type I and IV Journal Article Future Microbiology, 2020. Abstract \| Links \| BibTeX @article{Pavle2020, title = {Mysterious path of Borrelia spielmanii: spreading without morphological alteration of collagen type I and IV}, author = {Banović Pavle and Ivan Čapo and Dejan Ogorelica and Nenad Vranješ and Simin Verica and Dušan Lalošević}, url = {https://www.futuremedicine.com/doi/10.2217/fmb-2019-0217}, doi = {https://doi.org/10.2217/fmb-2019-0217}, year = {2020}, date = {2020-01-06}, journal = {Future Microbiology}, abstract = {The majority of suggested mechanisms of Borrelia spreading inside erythema migrans (EM) are developed from in vitro studies and animal models. This report is the first to describe pathomorphological substrate of EM caused by Borrelia spielmanii in humans, addressing the hypothesis of enhanced Borrelia penetration through extracellular matrix. In the process of ruling out of atypical Masters’ disease, we conducted a punch biopsy of suspected EM and a two-tier serology testing for Lyme borreliosis, where we registered antibodies against B. spielmanii. Skin biopsy showed CD4+ and CD8+ lymphocyte involvement and high activity of matrix metalloproteinase 9. No alterations were detected in distribution and morphology of collagen type I and IV. Therefore, it is suggested that other mechanisms should be considered as major contributing factors to local spreading of B.spielmanii.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Close The majority of suggested mechanisms of Borrelia spreading inside erythema migrans (EM) are developed from in vitro studies and animal models. This report is the first to describe pathomorphological substrate of EM caused by Borrelia spielmanii in humans, addressing the hypothesis of enhanced Borrelia penetration through extracellular matrix. In the process of ruling out of atypical Masters’ disease, we conducted a punch biopsy of suspected EM and a two-tier serology testing for Lyme borreliosis, where we registered antibodies against B. spielmanii. Skin biopsy showed CD4+ and CD8+ lymphocyte involvement and high activity of matrix metalloproteinase 9. No alterations were detected in distribution and morphology of collagen type I and IV. Therefore, it is suggested that other mechanisms should be considered as major contributing factors to local spreading of B.spielmanii. Close https://www.futuremedicine.com/doi/10.2217/fmb-2019-0217 doi:https://doi.org/10.2217/fmb-2019-0217 Close

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2019

Gordana, Smieško; Vera, Gusman; Pavle, Banović

Jack of all trades spotted in the Clinical Centre of Vojvodina – first detection of Aeromonas hydrophila from urinary tract infection samples Journal Article

Srpski arhiv za celokupno lekarstvo, 2019.

Abstract | Links | BibTeX

Lalošević, Dušan; Banović, Pavle; Cvjetković, Boris; Stumpf, Iris; Lalošević, Vesna; Vranješ, Nenad

ULCERATED NONHEALING SUBCUTANEOUS NODULE AT THE CAT – A CASE OF MYCETOMA AND FAMILIAL DERMATOMYCOSIS OF OWNERS Journal Article

Medical Data, 11 (2), pp. 107-109, 2019.

Abstract | BibTeX

5 entries « ‹ 2 of 2 › »

Other publicationsOther publications

100

YEARS

OF PASTEUR INSTITUTE NOVI SAD

The founder and first director was Dr. Adolf Hempt, whose rabies vaccine was used in most European countries, until the mid-eighties of the last century.